The fifth Medical Objective of the project is to provide a model sensitive to change in order that will facilitate the testing of pharmaceutical and non-pharmaceutical interventions, which will be designed to delay, arrest or even reverse the transition to frailty, can be tested (MO5).

Development of a personalized, predictive, physiological and environment-aware virtual patient model (MO5) will be performed that will help to appreciate and formally represent frailty and aging related disorders including major co-morbidities. This model will be able (a) to associate the adopted dynamic parameters with ageing related risks and (b) to assess the proximity of an individual’s behaviour to the goals set by a supervising health professional. In this process we will estimate, analyze and model the relation of specific co-morbidities emphasizing on gait disorders, social behaviour, sarcopenia and frailty.